C-Bactam is a combination of cefepime hydrochloride, a fourth generation cephalosporin, and sulbactam sodium, a beta-lactamase inhibitor.
Cefepime hydrochloride, is a semi-synthetic, broad spectrum antibiotic for parenteral administration. Cefepime hydrochloride is a white to pale yellow powder and a molecular weight of 571.5 g/mol. It is highly soluble in water. Sulbactam sodium is a derivative of basic penicillin nucleus. It is an irreversible ß-lactamase inhibitor. Cefepime and sulbactam act synergistically and have a broad spectrum of in vitro activity that encompasses a wide range of ESBL gram positive and gram negative bacteria. Cefepime exhibits rapid penetration into gram-negative bacterial cells. Cefepime and sulbactam combination has been shown to be active against ESBL.